|
Chỉ định và Liều dùng
Oral
Urine alkalinisation Adult: 15-30 mL bid-tid.
Child: <7 yr 2 mL tid; 7-12 yr 5 mL tid. |
|
Chống chỉ định
Hyperosmolar states, HTN, oedema.
|
|
Thận trọng
Hypocalcaemia, hypoventilatory states, alkalosis. Renal disease. Childn including neonates. Pregnancy and lactation.
|
|
Tác dụng không mong muốn
Mild diuresis, stomach cramps, flatulence, diarrhoea, GI ulceration, hypokalaemia, metabolic alkalosis, tiredness, dyspnoea, anxiety, mood swings.
|
|
Quá liều
Symptom: Metabolic alkalosis. Management: Symptomatic and supportive treatment.
|
|
Tương tác
Enhances elimination of salicylates and barbiturates. May increase the half-life of quinidine, ephedrine, pseudoephedrine. Additive effect w/ Na retention caused by corticosteroids. Potentiates renal excretion of tetracycline. Hypochloraemic alkalosis may occur w/ concomitant K-depleting diuretics.
|
|
Tương tác với thức ăn
Avoid alcohol.
|
|
Ảnh hưởng đến kết quả xét nghiệm
May interfere w/ urine ketone test.
|
|
Tác dụng
Description:
Mechanism of Action: Disodium hydrogen citrate is metabolised to bicarbonate, which then increases urinary pH by increasing the excretion of free bicarbonate ions, thereby increasing the solubility of cystine in the urine and the ionization of uric acid to more soluble urate ion. Onset: <1 min. Duration: 4-6 hr. |
|
Phân loại MIMS
|
|
Tài liệu tham khảo
Buckingham R (ed). Bicarbonate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 27/04/2016 .
|
Đăng xuất
